abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutc...

journal_title：Experimental dermatology

authors： van der Kooi-Pol MM,Veenstra-Kyuchukova YK,Duipmans JC,Pluister GN,Schouls LM,de Neeling AJ,Grundmann H,Jonkman MF,van Dijl JM

更新日期：2012-06-01 00:00:00

abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

journal_title：Experimental dermatology

authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC-hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII coll...

journal_title：Experimental dermatology

authors： Ettinger M,Gratz IK,Gruber C,Hauser-Kronberger C,Johnson TS,Mahnke K,Thalhamer J,Hintner H,Peckl-Schmid D,Bauer JW

更新日期：2012-05-01 00:00:00

abstract：:Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerg...

journal_title：Experimental dermatology

authors： Sarchio SN,Kok LF,O'Sullivan C,Halliday GM,Byrne SN

更新日期：2012-04-01 00:00:00

abstract：:In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo term...

journal_title：Experimental dermatology

authors： Doupé DP,Jones PH

更新日期：2012-04-01 00:00:00

abstract：:Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here, we demonstrate that - different from healthy controls - vaspin serum levels i...

journal_title：Experimental dermatology

authors： Saalbach A,Vester K,Rall K,Tremel J,Anderegg U,Beck-Sickinger AG,Blüher M,Simon JC

更新日期：2012-04-01 00:00:00

abstract：:Interferon-γ (IFNγ)-induced collapse of hair follicle (HF) immune privilege (IP) is a key element in the pathogenesis of alopecia areata. In this pilot study, we investigated whether the immunosuppressive neuropeptide, calcitonin gene-related peptide (CGRP), can protect from and/or restore IFNγ-induced HF-IP collapse....

journal_title：Experimental dermatology

authors： Kinori M,Bertolini M,Funk W,Samuelov L,Meyer KC,Emelianov VU,Hasse S,Paus R

更新日期：2012-03-01 00:00:00

abstract：:In mammals, the skin can form complex global and local patterns to meet diverse functional requirements in different parts of the body. To date, the fundamental principles that underlie skin patterning remain poorly understood because of the involvement of multiple interacting processes. Genes involved in the planar c...

journal_title：Experimental dermatology

authors： Chen J,Chuong CM

更新日期：2012-02-01 00:00:00

abstract：:Given that metastasized melanoma is a fatal disease in most cases, it is tempting to develop strategies to a priori prevent metastasis. We have stimulated the pulmonary innate immune system by macrophage-activating lipopeptide-2 (MALP-2), a specific agonist at Toll-like receptor (TLR) 2/6, and investigated its impact ...

journal_title：Experimental dermatology

authors： Schill T,Schön MP,Pletz N,Emmert S,Schön M

更新日期：2012-02-01 00:00:00

abstract：:White adipose tissue is known to be involved in numerous physiological processes such as insulin-mediated functions, lipid and glucose metabolism, vascular changes and coagulation. These processes are mainly mediated by adipokines that are secreted either from adipocytes or cells of the stromal-vascular fraction of ad...

journal_title：Experimental dermatology

authors： Gerdes S,Osadtschy S,Rostami-Yazdi M,Buhles N,Weichenthal M,Mrowietz U

更新日期：2012-01-01 00:00:00

abstract：:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

journal_title：Experimental dermatology

authors： Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

更新日期：2011-12-01 00:00:00

abstract：:Glomuvenous malformations (GVM) are hamartomas characterized histologically by glomus cells, which should be distinguished from glomus tumors. Familial GVM are rare, often present as multiple lesions, and exhibit familial aggregation, with autosomal dominant transmission. GVM are caused by mutations of the glomulin (G...

journal_title：Experimental dermatology

authors： Borroni RG,Narula N,Diegoli M,Grasso M,Concardi M,Rosso R,Cerica A,Brazzelli V,Arbustini E

更新日期：2011-12-01 00:00:00

abstract：:Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations ...

journal_title：Experimental dermatology

authors： Arakawa M,Dainichi T,Ishii N,Hamada T,Karashima T,Nakama T,Yasumoto S,Tsuruta D,Hashimoto T

更新日期：2011-12-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....

journal_title：Experimental dermatology

authors： Hashimoto Y,Takaoka A,Sugimoto M,Honma Y,Sakurai T,Futaki N,Arai I

更新日期：2011-10-01 00:00:00

abstract：:It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We investigated the effects of topically applied corticosteroids betamethasone...

journal_title：Experimental dermatology

authors： Jensen JM,Ahrens K,Meingassner J,Scherer A,Bräutigam M,Stütz A,Schwarz T,Fölster-Holst R,Harder J,Gläser R,Proksch E

更新日期：2011-10-01 00:00:00

abstract：:In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc). Serum adiponectin concentrations were measured in 32 patients with SSc, 10 patients with SLE, 12 patients with dermatomyositis patients and 13 healthy subjects with specific enzyme-linked immunoso...

journal_title：Experimental dermatology

authors： Arakawa H,Jinnin M,Muchemwa FC,Makino T,Kajihara I,Makino K,Honda N,Sakai K,Fukushima S,Ihn H

更新日期：2011-09-01 00:00:00

abstract：:TNF is critically involved in the pathogenesis of psoriasis. TL1A is a TNF-like cytokine, which, after binding to death domain receptor DR3, provides costimulatory signals to lymphocytes, amplifies Th1- and Th17-mediated immune responses and induces apoptotic cell death. These functions are inhibited when TL1A associa...

journal_title：Experimental dermatology

authors： Bamias G,Evangelou K,Vergou T,Tsimaratou K,Kaltsa G,Antoniou C,Kotsinas A,Kim S,Gorgoulis V,Stratigos AJ,Sfikakis PP

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS:To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 2...

journal_title：Experimental dermatology

authors： Dessinioti C,Tzannis K,Sypsa V,Nikolaou V,Kypreou K,Antoniou C,Katsambas A,Stratigos AJ

更新日期：2011-08-01 00:00:00

abstract：:Psoriasis is now considered to be a chronic, immune-mediated and inflammatory skin disease. As the precise cause of psoriasis remains unknown, its treatment is challenging for dermatologists. Keratin 17 (K17), an intermediate filament protein, is highly expressed in psoriatic lesions, while not normally expressed in h...

journal_title：Experimental dermatology

authors： Chang T,Sun L,Wang Y,Wang D,Li W,Li C,Gao T,Liu Y,Wang G

更新日期：2011-07-01 00:00:00

abstract：:The 'matrikine' concept claims that processing of the precursors for collagen results in the formation of peptides such as KTTKS which in turn augments extracellular matrix (ECM) production. In the present study, we show the development of an anti-ageing active from an in silico approach by molecular design resulting ...

journal_title：Experimental dermatology

authors： Farwick M,Grether-Beck S,Marini A,Maczkiewitz U,Lange J,Köhler T,Lersch P,Falla T,Felsner I,Brenden H,Jaenicke T,Franke S,Krutmann J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Previously, we have reported a frequent association of active plaque psoriasis with inflammation-mediated cytomegalovirus (CMV) reactivation. OBJECTIVES:This study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immune response. PATIENTS/ME...

journal_title：Experimental dermatology

authors： Weitz M,Kiessling C,Friedrich M,Prösch S,Höflich C,Kern F,Volk HD,Sterry W,Asadullah K,Döcke WD

更新日期：2011-07-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：:Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is an X-linked genodermatosis with congenital atrichia being the most prominent feature. Recently, we have shown that functional deficiency of MBTPS2 (membrane-bound transcription factor protease site 2) - a zinc metalloprotease essential for cholestero...

journal_title：Experimental dermatology

authors： Oeffner F,Martinez F,Schaffer J,Salhi A,Monfort S,Oltra S,Neidel U,Bornholdt D,van Bon B,König A,Happle R,Grzeschik KH

更新日期：2011-05-01 00:00:00

abstract：:Recently, 3% diclofenacnatrium gel (diclofenac) was introduced for the treatment of actinic keratoses. Data on photocarcinogenesis of topical diclofenac are limited, and we wished to investigate whether topical diclofenac can accelerate photocarcinogenesis using simulated solar radiation (SSR). Diclofenac was applied ...

journal_title：Experimental dermatology

authors： Lerche CM,Philipsen PA,Poulsen T,Wulf HC

更新日期：2011-04-01 00:00:00

abstract：:There is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging sign...

journal_title：Experimental dermatology

authors： Boehncke WH,Boehncke S,Tobin AM,Kirby B

更新日期：2011-04-01 00:00:00

abstract：:We previously reported that sphingosine-1-phosphate (S1P) decreases melanin synthesis via extracellular signal-regulated protein kinase (ERK) activation and microphthalmia-associated transcription factor (MITF) degradation. Although FTY720 is an S1P structural analogue, the effects of FTY720 on melanogenesis are not c...

journal_title：Experimental dermatology

authors： Lee JE,Kim SY,Jeong YM,Yun HY,Baek KJ,Kwon NS,Park KC,Kim DS

更新日期：2011-03-01 00:00:00

abstract：:Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for the development and homoeostasis of the epidermis and hair follicles. However, more detailed studies have been precluded by the shortened lifespan of Egfr knockout mice. We employed the mouse line Wa5 (carrying ...

journal_title：Experimental dermatology

authors： Dahlhoff M,Rose C,Wolf E,Schneider MR

更新日期：2011-03-01 00:00:00

abstract：:The correlation between the degrees of integrity and cohesion in healthy human Stratum corneum (SC) and the properties of the SC lipid matrix could be examined non-invasively in vivo using ATR-FTIR spectroscopy and measurements of pH, conductance, and transepidermal water loss (TEWL) taken in the course of tape-stripp...

journal_title：Experimental dermatology

authors： Berthaud F,Boncheva M

更新日期：2011-03-01 00:00:00

abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

journal_title：Experimental dermatology

authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

更新日期：2011-02-01 00:00:00

abstract：:Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease-activated receptors (PAR(1) and PAR(2) ) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR(1) immunoreactivity was positive in fibroblas...

journal_title：Experimental dermatology

authors： Cevikbas F,Seeliger S,Fastrich M,Hinte H,Metze D,Kempkes C,Homey B,Steinhoff M

更新日期：2011-01-01 00:00:00

abstract：:Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of μ-opioid peptides, secreted by tumor cells, on anti-tumor immune responses. For this purpose, tumor growth was studied in wild-type and μ-opioid receptor-deficient (MOR-/-) mice injected with...

journal_title：Experimental dermatology

authors： Boehncke S,Hardt K,Schadendorf D,Henschler R,Boehncke WH,Duthey B

更新日期：2011-01-01 00:00:00

abstract：:Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

journal_title：Experimental dermatology

authors： Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

更新日期：2010-12-01 00:00:00

abstract：:Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...

journal_title：Experimental dermatology

authors： Flohil SC,de Vries E,van Meurs JB,Fang Y,Stricker BH,Uitterlinden AG,Nijsten T

更新日期：2010-12-01 00:00:00

abstract：:Inflammation is a crucial step in the development of allergic contact dermatitis. The primary contact with chemical allergens, called sensitization, and the secondary contact, called elicitation, result in an inflammatory response in the skin. The ability of contact allergens to induce allergic contact dermatitis corr...

journal_title：Experimental dermatology

authors： Lass C,Merfort I,Martin SF

更新日期：2010-11-01 00:00:00

abstract：:Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in h...

journal_title：Experimental dermatology

authors： Vockel M,Breitenbach U,Kreienkamp HJ,Brandner JM

更新日期：2010-10-01 00:00:00